I had to switch out my 2X2 for a Roland UM ONE MKII. it runs right into a serial MTP AV and I was only using the one port in any case. in my case on high sierra, the 32bit Midi driver of the 2X2, was hobbling another unit needing to run on the core Midi system, using Mac OSβs 64bit Bluetooth Midi driver.
after looking into it a little, it seems 64bit Bluetooth Midi drivers canβt live alongside a 32bit Midi driver. I think itβs because, if Bluetooth Midi needs to work at 64bit into the core Midi system, then a 32bit Midi driver may force the USB subsystem, to pull down to 32bit. potentially something along those lines. in the case of the BT Midi, it simply won't work untill the 2X2 driver was taken out of its enclosing folder and moved somewhere else. or deleted. I moved mine to a desktop folder.
so Iβd think that if this is true and apple already know it, then apple tend to manage these deprecations of driver bit depth support, in an incremental and phased fashion. but the strategy is to not really mention anything about any of it.
that took some investigating as it goes. but this video explained that this was probably my specific issue.
the guy in the video is having the same problem, but with a driver for his waves soundgrid.
I can only imagine the amount of Roli Blocks and Soundgrid problems, which occurred
due to the effects of phased deprecations. this video is a good exhibit for the case.