I did a comparison between my Symhony IO MK1 and Orion Studio I had for 10 days. They do sound more different than I imagined two units can sound. Apogee sounds more true to the source, more natural, bass is tighter and also more extended, but trues. Antelope has a hi end sheen and softer mids, more in a hi-fi way and more emphasis in the 100Hz.
Initially I found Antelope to sound thin compared to Apogee, but I grew to really like its sound. Still, Apogee objectively sounds more neutral. What goes in is what you hear. Orion sounds more processed.
I also have RME Babyface Pro and Apollo 8P. They both sound much closer to Apogee than to Antelope. It goes to show me Antelope really has a specific sound, which is very very open and wide but not harsh (due to the recessed upper midrange).