My understanding is that the higher the buffer size, the easier it is for your computer's processor to handle larger projects. At 48 kHz, my MOTU M2 goes to a maximum buffer size of 4096 samples. Are there any other interfaces on the market that go higher?

Mac or PC?

Going higher won't really make a difference due to diminishing returns. If you're getting buffer underruns at 4096, doubling it to 8192 won't really help since the issue is your system is simply unable to process the audio fast enough for realtime playback.

I remember the good old days where we had 750ms latency and thought it was good.

Ah the Yamaha DSP Factory.....

You need a soundcard that can do more work at any given buffer size, and that's RMEs' gig

PC.

Thank you. Will check RME out. I've been interested in the Babyface.

Also, it depends on the DAW you are using, many DAWs (Logic, Cubase, S1…) have so called “hybrid” engines, where tracks that are not record armed are played through a much higher “safety buffer” anyway and the buffer settings of the audio interface isn’t as relevant.
Also, with higher buffer sizes, it is advisable to have an eye on automation, as it a) can lose precision and b) actually produce nonsense (I’ve had that with specific Cubase versions where a buffer size of higher than 2048 would produce some sorts of “hallucinations” in the render. A bug of course).

This is interesting! I am on Studio One. Do you know if these issues are only during playback, or also during bouncing?

Loved that card and its integration with cubase. As long as you didn't need soft synths it was a powerful solution.