Unchecking the time sync only reduces the dropouts. You need to also uncheck the location sync in the Time Zone tab, but even then you're only reducing the dropouts. Any time the T2 chip tries to sync, it will overload the USB2.0 bus, causing dropouts. There is no way any musician should go on stage with a 2018 [Mac] and a USB2.0 audio interface directly connected to it. The only solutions are 1) Get a Thunderbolt or USB3.0 audio interface, or 2) Use a Certified Thunderbolt 3 powered hub (not a bus-powered or cheap non-certified hub) - Cable Matters has a solution for $169 on Amazon, but most of those hubs are at least $200-300. Using a certified TB3 hub creates a separate external USB2.0 bus, in which you can run your USB2.0 audio interface. The cheap hubs do not work because they don't run on the TB3 bus, and therefore they don't create their own separate USB2.0 bus, which means you're going to get dropouts.