there's another thread called 'Apogee Duet severe dropouts problems' where I posted my horrifying experience with this soundcard.
Apogee Duet 2 Severe Audio Drop Out Issues with 2015 Macbook Pro and Yosemite OSX
I'm speechless about Apogee that is not taking an official position about this big mess!
I've been investigating the cause of this problem far and wide. I tried all the mentioned processes about drivers, osx updates, firmware, pram reset, smc reset and also apogee official service inspection and tests...
I still suspect (and I really hope) that it's not an hardware problem...
The official distribution assistance service in Italy has no clue and they're saying there are major problems with the circuits of these soundcards due to the amount of complaints.
So again why there is no official explanation about that...
For any further information and investigation you can check the other thread mentioned above.