Thanks for the responses, everyone!
This actually led to me to mute the drums and bass, and run the TBC2 through it’s paces (since I kept assuming those were where my real problems were).
Turns out I had too much low end in the acoustic guitars and they were muddying things up and leading to an inflated low end.
I was worried that, either rolling off or scooping too much low end in the guitars, would end up sounding too thin on the stripped down parts (a common problem for me), but doing so while watching the TBC2 allowed me to scoop to a suitable point and not lose any of the darker guitar feel I was looking for.
When I put the bass and drums back in the mix, it was like magic. Everything opened up and I could turn down the bass and kick a bit, and now everything fits solid.
Dare I say a lesson was learned?
Thanks all!