Are you using the driverkit version of the RME driver or the kernel version of the driver?
Do you have the short offset turned on or off?
Have you reduced the macOS security policy (needed for kernel version) done from recovery mode?
What exact driver version are you using, what exact firmware are you using, and what full version number of your macOS Ventura?
All these things will matter (give the full version numbers)
(Your issue seems distinctly yours so it must be something about your choices. We have a lot of MADIXT deployed working with Pro Tools and no issues)
You also never answered this question from my post 2
Quote:
What are your playback engine settings in Pro Tools?
Which Pro Tools version are you using? Are you running Pro Tools in rosetta mode?
And, finally, why are you on Ventura? Apple rolled out a lot of hardware fixes for the M1 chip and M1 system hardware with every macOS version since the release of the chips. That's the only way to get those hardware fixes (which includes system hardware firmware updates.)
macOS Sequoia is terrible for audio, but going up to Sonoma is pretty safe.