Problems like this are almost always related to a badly behaved PC process or device driver. You can use a tool like this one to help you figure out what is happening.
Respendence LatencyMon
You'll undoubtedly see a latency spike when the problem occurs. Now your job is to figure out what's causing it.
Open Task Manager to see what is running in background. Many processes have strange names, but a web search will tell you what it is and whether it is essential to your system or not. If you open your System Tray, you'll often see icons for programs that you wouldn't have guessed are hanging around all the time. Right click to close them and tell them not to run at start up.
The fact that this disturbance happens regularly but rarely suggests some scheduled process like an update check that needs to be turned off. Open Task Scheduler to see what it was that started running when the problem occurred. If you see a task that's scheduled to rerun in just over an hour, that's a dead giveaway for your problem.
Driver problems tend to manifest more frequently or be triggered by some particular user behavior like opening browser or resizing a window. Common culprits are bus-hogging graphics cards and network adapters. The problem is usually fixable by dialing back acceleration parameters or downloading a different driver.
I notice that you posted your question to a general Magix support forum. That's not where Samplitude and Sequoia power users hang out. Instead, join the dedicated
Samplitude/Sequoia Support Forum
David L. Rick
Seventh String Recording