Whenever it's in the budget, and practical, I prefer mixing OTB. That is not to say I don't enjoy mixing ITB. I have a private studio at home and I do most of my mixing here. I have some cool hardware (API EQ's, Compex stereo limiter, Transient Designer compressors and some effects boxes. I also have all the Universal Audio plugins. I'm always happy with the results.

When I can mix on a Neve, that is my preference. There is a definite difference in the sound. I would hope so, for something that costs so much.