I realize this is an older thread but thought this info might be useful to those out there who are still using, or trying to use, the UA-1000 with Windows 10...
Although the above method initially worked for me (using the Vista 64 bit drivers and manually installing them through the device manager) it did not allow access to the UA-1000's control panel in a standalone mode - I was only able to access it within Cubase by setting it as my audio device. As I wanted to specifically use the UA-1000 as a mixer, patchbay, and A/D converter while simultaneously using a different device as my audio interface within Cubase, it presented a problem.
In retrospect I'm not sure the first step I took is completely necessary and you may be able to skip it but this sequence worked and also allowed me to run the Roland Windows 7 64 bit driver (credit for this step goes to Fyba, you will need to read his tutorial here:
The ultimate guide to get your Roland/Edirol devices to work with Windows 10. [Updated] | Cakewalk Forums). The difference in this case is that within the inf file you instead want to replace '6.1' (not 6.2) with '10'. Once that file is edited and saved, use the same installation method as described above in this thread for the Vista drivers.
The final and likely most important step is to go to C:\WINDOWS\system32\RDCP1034.CPL and right click on the file, then go to Properties. Within this window under the 'General' settings you should see a box at the bottom with a toggle that says 'Unblock' - toggle it on and accept the warning. To make life easier I would suggest to then create a shortcut to access this file. Assuming your UA-1000 is connected via USB, clicking on this shortcut should now instantly open up the UA-1000's control panel and enable you to edit its functions as a standalone device.